The use of specific remineralizing agents in toothpastes may help to prevent caries and treat human enamel. In this study, applied nanotechnologies were used to develop toothpastes with remineralizing properties. Hydroxyapatite nanocrystals, with size, morphology, chemical composition comparable with that of enamel, were synthesized by wet chemical method. The remineralizing effect was studied with a scanning electron microscopy (SEM) of enamel previously demineralized. The SEM images demonstrated differences in micro surface at each step. The rate of remineralization seems to be compatible with the development of toothpastes with remineralizing effect. In conclusion, toothpaste containing nano-sized hydroxyapatite has the potential to remineralize an incipient caries lesion. In addition, the use of fluoride in toothpaste contains nano- hydroxyapatite might promote formation of nano fluoro hydroxyapatite in enamel surface.

Keywords: Hydroxyapatite, Nanocrystals, Human enamel, Remineralization, Toothpaste, Dental materials.