Articles
  • Synthesis and characterization of biphasic calcium phosphate ceramics using a sponge coating method
  • Deuk Yong Leea,*, Do-Hyeon Kima, Bae-Yeon Kimb, Jeong Yoon Parkc and Jun-Kang Leec
  • aDepartment of Biomedical Engineering, Daelim University, Anyang 13916, Korea bDepartment of Materials Science and Engineering, Incheon National University, Incheon 22012, Korea cNeobiotech Inc., Ltd., Seoul 08382, Korea
Abstract
Biphasic calcium phosphate (BCP) bone grafts were successfully synthesized using the 45 ppi polyurethane sponge coating method. XRD results revealed that the BCP scaffolds were mainly composed of hydroxyapatite and β-tricalcium phosphate (β-TCP). As the number of BCP coatings increased from 1 to 5, the pore size and the wall size decreased from 480 ± 93 μm to 306 ± 120 μm and increased from 104 ± 25 μm to 186 ± 40 μm, respectively. The BCP scaffolds coated once, twice, three times, four times and five times, exhibited average cell viability of 106%, 109%, 114%, 107%, and 93%. The BCP scaffolds showed no evidence of causing cell lysis or toxicity. In addition, the cell proliferation results suggested that L-929 cells adhered well to the BCP scaffolds and proliferated continuously with increasing time, indicating that the BCP powders are highly applicable to the synthetic bone grafts.

Keywords: Hydroxyapatite (HP), β-tricalcium phosphate (β-TCP), Biphasic calcium phosphate (BCP), Scaffold, Cytotoxicity.

This Article

  • 2018; 19(1): 15-19

    Published on Feb 28, 2018

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